Pharmacology: Mechanism of Action: Econazole is an imidazole antifungal. It is used topically in the treatment of superficial candidiasis and in dermatophytosis and pityriasis versicolor. Triamcinolone is effective in the treatment of corticosteroids-responsive dermatoses because of their anti-inflammatory, antipruritic and anti-allergic actions. Econazole is absorbed little through skin or mucous membranes. Triamcinolone is absorbed from sites of topical application. When applied topically, particularly to large areas, when the skin is broken, or under occlusive dressings, sufficient triamcinolone may be absorbed to give systemic effects. Triamcinolone has a half-life in plasma about 2 to over 5 hours. It is bound to plasma albumin to a much smaller extent than hydrocortisone. Triamcinolone is metabolized mainly in the liver but also in the kidney and are excreted in the urine.
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